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We’ve made ordering and prescribing Upneeq into a simple, modernized process. Our friendly and knowledgeable customer support team is ready to help you should you need it.

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How to bring Upneeq to your practice

For eye care professionals
1
Send patient’s prescription for Upneeq directly to RVL Pharmacy (see e-Prescribing details below).
2
Pharmacy contacts patient to review the prescription, collect payment, and answer any questions.
3
Upneeq is shipped directly to the patient’s home or preferred destination within 2-5 business days following payment.
Prescribing Directions:
Select RVL Pharmacy in your EMR.
Location: Sayreville, NJ 08872
NPI: 1770193757
NCPDP: 3157369
Fax Number: 844-567-3937
Phone Number: 844-RVL-EYES (844-785-3937)
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Frequently asked questions

Find additional FAQsPatient PDF
  • Eye Care Professionals can prescribe Upneeq by directly contacting RVL Pharmacy.

  • Medical Aesthetics Professionals can prescribe Upneeq by signing up through our portal at this link.

  • For detailed steps scroll up to the How To section above.

  • STEP 1
    Cut open child-resistant foil pouch and remove single-use vial.

  • STEP 2
    Apply one drop to each affected eye as directed, once a day or on days when eyelids need a lift.

  • Tilt head back to apply Upneeq.

    Don’t touch the eye with the tip of the vial or touch the tip of the vial to any other surface.

    Throw the single-use vial away immediately after applying drops. Vials should not be re-used after opening.

    If wearing contact lenses, remove lenses before applying Upneeq, and wait 15 minutes before putting lenses back in.

    If more than one topical ophthalmic drug is being used, the drugs should be administered at least 15 minutes between applications.

    Upneeq should be used only as directed.
    Upneeq is designed to only be applied as an eyedrop. Each single-use vial contains enough solution for one drop in each affected eye. Keep child-resistant foil pouch sealed until ready to use. The solution should never be swallowed or ingested in any way. Store Upneeq at 68°F–77°F (20°C–25°C) and protect from excessive heat. Keep out of reach of children.

  • Eye Care Professionals:
    • When the prescription is ready, RVL Pharmacy will contact the patient directly, and the patient will be able to pay over the phone by credit card.
    • RVL Pharmacy does not accept payments from insurance providers. Upneeq is available directly to patients through a fully transparent pricing model outside of the insurance process.
  • Medical Aesthetics Professionals:
    • Patients pay directly at your practice.
  • Upneeq is available in a case of 30 individually foil-pouched single patient-use vials (NDC 73687-062-32).
  • Upneeq should be stored at 68°F to 77°F (20°C to 25°C) and should be protected from excessive heat. It should be kept out of the reach of children.

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IMPORTANT SAFETY INFORMATION


What is UPNEEQ?

UPNEEQ® (oxymetazoline hydrochloride ophthalmic solution), 0.1% is a prescription eyedrop used to treat acquired blepharoptosis (low-lying lids) in adults.


What warnings and precautions are associated with UPNEEQ?

  • Low-lying lids may be related to conditions such as stroke and/or brain aneurysm, Horner syndrome, myasthenia gravis, loss of the ability to move eye muscles, eye infection and eye tumors. Tell your doctor if you have any of these conditions.
  • UPNEEQ is a type of medication that may affect your blood pressure. If you have heart disease, uncontrolled high or low blood pressure, or feel faint at rest or when quickly standing up, you should call your doctor if your symptoms get worse.
  • Patients with reduced blood flow to the brain or heart, or patients who experience eye or mouth dryness due to an immune system disorder (Sjögren’s syndrome), should use care when taking UPNEEQ. Call your doctor immediately if you feel your symptoms may be getting worse.
  • UPNEEQ may increase the risk of eye pressure due to fluid buildup (angle-closure glaucoma) in patients with untreated narrow-angle glaucoma. Call your doctor immediately if you feel increased pressure in your eye after using UPNEEQ.
  • Do not let the tip of the UPNEEQ vial touch your eye or any other surface. This can help prevent eye injury or contamination. Each UPNEEQ vial is for one-time use and should be discarded after being used.

What are the most common side effects of UPNEEQ?

The most common adverse reactions with UPNEEQ (occurring in 1-5% of patients) were eye inflammation, eye redness, dry eye, blurred vision, eye pain at time of use, eye irritation, and headache.


What should my doctor know about before prescribing me UPNEEQ?


  • Your doctor should review your full medical history before prescribing UPNEEQ.
  • UPNEEQ belongs to a class of medication (alpha-adrenergic agonists) that may affect your blood pressure. Use UPNEEQ carefully if you currently take an alpha-adrenergic agonist medication to treat heart disease or an enlarged prostate. Patients taking beta-blockers, or other medications to treat hypertension or an abnormal heartbeat, should also be careful when using UPNEEQ.
  • Patients who use a certain class of antidepressant medication (monoamine oxidase inhibitors) should also be careful when using UPNEEQ, as it may affect the way your body absorbs the medication.

These are not all of the possible side effects of UPNEEQ. Tell your doctor if you have any side effect that bothers you or does not go away. Call your doctor for medical advice about side effects.
To report side effects or product complaints, contact RVL Pharmaceuticals at 1-877-482-3788. You may also report side effects to the FDA by calling 1-800-FDA-1088 or visit www.fda.gov/medwatch.
This is a summary of the most important safety information for UPNEEQ. For more in-depth safety information, please review the full Prescribing Information for UPNEEQ.

IMPORTANT SAFETY INFORMATION


What is UPNEEQ?

UPNEEQ® (oxymetazoline hydrochloride ophthalmic solution), 0.1% is a prescription eyedrop used to treat acquired blepharoptosis (low-lying lids) in adults.


What warnings and precautions are associated with UPNEEQ?

  • Low-lying lids may be related to conditions such as stroke and/or brain aneurysm, Horner syndrome, myasthenia gravis, loss of the ability to move eye muscles, eye infection and eye tumors. Tell your doctor if you have any of these conditions.
  • UPNEEQ is a type of medication that may affect your blood pressure. If you have heart disease, uncontrolled high or low blood pressure, or feel faint at rest or when quickly standing up, you should call your doctor if your symptoms get worse.
  • Patients with reduced blood flow to the brain or heart, or patients who experience eye or mouth dryness due to an immune system disorder (Sjögren’s syndrome), should use care when taking UPNEEQ. Call your doctor immediately if you feel your symptoms may be getting worse.
  • UPNEEQ may increase the risk of eye pressure due to fluid buildup (angle-closure glaucoma) in patients with untreated narrow-angle glaucoma. Call your doctor immediately if you feel increased pressure in your eye after using UPNEEQ.
  • Do not let the tip of the UPNEEQ vial touch your eye or any other surface. This can help prevent eye injury or contamination. Each UPNEEQ vial is for one-time use and should be discarded after being used.

What are the most common side effects of UPNEEQ?

The most common adverse reactions with UPNEEQ (occurring in 1-5% of patients) were eye inflammation, eye redness, dry eye, blurred vision, eye pain at time of use, eye irritation, and headache.


What should my doctor know about before prescribing me UPNEEQ?


  • Your doctor should review your full medical history before prescribing UPNEEQ.
  • UPNEEQ belongs to a class of medication (alpha-adrenergic agonists) that may affect your blood pressure. Use UPNEEQ carefully if you currently take an alpha-adrenergic agonist medication to treat heart disease or an enlarged prostate. Patients taking beta-blockers, or other medications to treat hypertension or an abnormal heartbeat, should also be careful when using UPNEEQ.
  • Patients who use a certain class of antidepressant medication (monoamine oxidase inhibitors) should also be careful when using UPNEEQ, as it may affect the way your body absorbs the medication.

These are not all of the possible side effects of UPNEEQ. Tell your doctor if you have any side effect that bothers you or does not go away. Call your doctor for medical advice about side effects.
To report side effects or product complaints, contact RVL Pharmaceuticals at 1-877-482-3788. You may also report side effects to the FDA by calling 1-800-FDA-1088 or visit www.fda.gov/medwatch.
This is a summary of the most important safety information for UPNEEQ. For more in-depth safety information, please review the full Prescribing Information for UPNEEQ.