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Why Upneeq?

Upneeq is the first and only FDA-approved eye drop that’s been clinically proven to quickly and safely lift low-lying eyelids. It offers a non-surgical eyelid lift, in an easy-to-use once daily eye drop.

If you have low-lying eyelids, learn how Upneeq can give a brighter, more awake-looking appearance.

BEFORE
AFTER
After
Before

Individual results may vary. Average upper eyelid lift with Upneeq in clinical studies was 1 mm.

Upneeq's eye‑opening benefits

Easy Application

Our single-use vials make it easy to apply and move on with your day. Just one eye drop per affected eye, once daily, has been clinically proven to lift low-lying eyelids.

Visible, Fast Results

Upneeq works to lift the upper eyelid quickly, with many users reporting a difference in as fast as 5 minutes. In clinical trials, 84% of them had some form of improvement in eyelid lift.

Improved Field of Vision

Upneeq doesn’t just improve the look of the eyes, lifted eyelids can increase upper field of vision. In clinical trials, 88% of patients reported some form of improvement in their upper field of vision.

No More Tired-Looking Eyelids

No one wants their eyes to look sleepy, droopy, or older. By lifting the upper eyelid, Upneeq opens your eyes, making them appear larger, making you look alert, and more awake.

PATIENT TESTIMONIALS

See what people say about their own
eye-opening experience

How Upneeq works

Upneeq opens eyes by targeting the muscles of the upper eyelid, and causing them to contract. This contraction moves the eyelid upward, opening the eye wider. When more of the iris and white of the eye are visible, eyes often appear bigger, with an improved field of vision.

Just one drop in each affected eye, once daily, gets visible results in as fast as 5 minutes, and can last up to 8 hours.

DO YOU HAVE LOW-LYING EYELIDS?

How it works video thumbnail

Individual results may vary. Average upper eyelid lift with Upneeq in clinical studies was 1 mm.

INSTRUCTIONS

How to apply Upneeq

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STEP 1

Cut open foil wrapper and remove single-use vial.

STEP 2

Apply one drop to each affected eye as directed, once a day or on days when your eyelids need a lift.

  • Tilt head back to apply Upneeq
  • Close your eyes and roll gently to allow the drop to coat the eye


Do not let the tip of the vial touch your eye or any other surface.
Upneeq vials are single-use only and should not be reused after opening.
After applying the drops, immediately discard the vial in the trash.

If you wear contact lenses, remove your lenses before applying Upneeq, and wait 15 minutes before putting your lenses back in.

If more than one topical ophthalmic drug is being used, the drugs should be administered at least 15 minutes between applications.

Upneeq should be used only as directed.

Upneeq is designed to only be applied as an eyedrop.

Each single-use vial contains enough solution for one drop in each affected eye.

The solution should never be swallowed or ingested in any way.

Store Upneeq at 68°F–77°F (20°C–25°C) and protect from excessive heat.

Keep out of reach of children.

Upneeq is safe and well-tolerated.

In clinical trials, Upneeq was proven to be safe and effective when used as directed.

Common side effects (seen in 1-5% of patients) included eye inflammation, eye redness, dry eye, blurred vision, instillation site pain, eye irritation, and headache

What warnings and precautions are associated with Upneeq?

Low-lying lids may be related to conditions such as stroke and/or brain aneurysm, Horner syndrome, myasthenia gravis, loss of the ability to move eye muscles, eye infection and eye tumors. Tell your doctor if you have any of these conditions.

Upneeq is a type of medication that may affect your blood pressure. If you have heart disease, uncontrolled high or low blood pressure, or feel faint at rest or when quickly standing up, you should call your doctor if your symptoms get worse.

Patients with reduced blood flow to the brain or heart, or patients who experience eye or mouth dryness due to an immune system disorder (Sjögren’s syndrome), should use care when taking Upneeq. Call your doctor immediately if you feel your symptoms may be getting worse.

Upneeq may increase the risk of eye pressure due to fluid buildup (angle-closure glaucoma) in patients with untreated narrow-angle glaucoma. Call your doctor immediately if you feel increased pressure in your eye after using Upneeq.

Do not let the tip of the Upneeq vial touch your eye or any other surface. This can help prevent eye injury or contamination. Each Upneeq vial is for one-time use and should be discarded after being used.

For more information, please view the Instructions for Use section in the full Prescribing Information.

Is Upneeq
right for you?

Low-lying eyelids, or acquired ptosis, is when the upper eyelid starts to droop in one or both eyes. This can contribute to a tired or aged appearance, which can affect self-esteem and your ability to see.

Upneeq lifts droopy, tired-looking eyelids for more awake and open-looking eyes. Use the interactive self-assessment below to evaluate your eyelids.

Please note that this is for preliminary self-assessment only. See a healthcare provider or aesthetic
professional, so they can accurately diagnose your type of low-lying lids.

IMPORTANT SAFETY INFORMATION


What is UPNEEQ?

UPNEEQ® (oxymetazoline hydrochloride ophthalmic solution), 0.1% is a prescription eyedrop used to treat acquired blepharoptosis (low-lying lids) in adults.


What warnings and precautions are associated with UPNEEQ?

  • Low-lying lids may be related to conditions such as stroke and/or brain aneurysm, Horner syndrome, myasthenia gravis, loss of the ability to move eye muscles, eye infection and eye tumors. Tell your doctor if you have any of these conditions.
  • UPNEEQ is a type of medication that may affect your blood pressure. If you have heart disease, uncontrolled high or low blood pressure, or feel faint at rest or when quickly standing up, you should call your doctor if your symptoms get worse.
  • Patients with reduced blood flow to the brain or heart, or patients who experience eye or mouth dryness due to an immune system disorder (Sjögren’s syndrome), should use care when taking UPNEEQ. Call your doctor immediately if you feel your symptoms may be getting worse.
  • UPNEEQ may increase the risk of eye pressure due to fluid buildup (angle-closure glaucoma) in patients with untreated narrow-angle glaucoma. Call your doctor immediately if you feel increased pressure in your eye after using UPNEEQ.
  • Do not let the tip of the UPNEEQ vial touch your eye or any other surface. This can help prevent eye injury or contamination. Each UPNEEQ vial is for one-time use and should be discarded after being used.

What are the most common side effects of UPNEEQ?

The most common adverse reactions with UPNEEQ (occurring in 1-5% of patients) were eye inflammation, eye redness, dry eye, blurred vision, eye pain at time of use, eye irritation, and headache.


What should my doctor know about before prescribing me UPNEEQ?


  • Your doctor should review your full medical history before prescribing UPNEEQ.
  • UPNEEQ belongs to a class of medication (alpha-adrenergic agonists) that may affect your blood pressure. Use UPNEEQ carefully if you currently take an alpha-adrenergic agonist medication to treat heart disease or an enlarged prostate. Patients taking beta-blockers, or other medications to treat hypertension or an abnormal heartbeat, should also be careful when using UPNEEQ.
  • Patients who use a certain class of antidepressant medication (monoamine oxidase inhibitors) should also be careful when using UPNEEQ, as it may affect the way your body absorbs the medication.

These are not all of the possible side effects of UPNEEQ. Tell your doctor if you have any side effect that bothers you or does not go away. Call your doctor for medical advice about side effects.
To report side effects or product complaints, contact RVL Pharmaceuticals at 1-877-482-3788. You may also report side effects to the FDA by calling 1-800-FDA-1088 or visit www.fda.gov/medwatch.
This is a summary of the most important safety information for UPNEEQ. For more in-depth safety information, please review the full Prescribing Information for UPNEEQ.

IMPORTANT SAFETY INFORMATION


What is UPNEEQ?

UPNEEQ® (oxymetazoline hydrochloride ophthalmic solution), 0.1% is a prescription eyedrop used to treat acquired blepharoptosis (low-lying lids) in adults.


What warnings and precautions are associated with UPNEEQ?

  • Low-lying lids may be related to conditions such as stroke and/or brain aneurysm, Horner syndrome, myasthenia gravis, loss of the ability to move eye muscles, eye infection and eye tumors. Tell your doctor if you have any of these conditions.
  • UPNEEQ is a type of medication that may affect your blood pressure. If you have heart disease, uncontrolled high or low blood pressure, or feel faint at rest or when quickly standing up, you should call your doctor if your symptoms get worse.
  • Patients with reduced blood flow to the brain or heart, or patients who experience eye or mouth dryness due to an immune system disorder (Sjögren’s syndrome), should use care when taking UPNEEQ. Call your doctor immediately if you feel your symptoms may be getting worse.
  • UPNEEQ may increase the risk of eye pressure due to fluid buildup (angle-closure glaucoma) in patients with untreated narrow-angle glaucoma. Call your doctor immediately if you feel increased pressure in your eye after using UPNEEQ.
  • Do not let the tip of the UPNEEQ vial touch your eye or any other surface. This can help prevent eye injury or contamination. Each UPNEEQ vial is for one-time use and should be discarded after being used.

What are the most common side effects of UPNEEQ?

The most common adverse reactions with UPNEEQ (occurring in 1-5% of patients) were eye inflammation, eye redness, dry eye, blurred vision, eye pain at time of use, eye irritation, and headache.


What should my doctor know about before prescribing me UPNEEQ?


  • Your doctor should review your full medical history before prescribing UPNEEQ.
  • UPNEEQ belongs to a class of medication (alpha-adrenergic agonists) that may affect your blood pressure. Use UPNEEQ carefully if you currently take an alpha-adrenergic agonist medication to treat heart disease or an enlarged prostate. Patients taking beta-blockers, or other medications to treat hypertension or an abnormal heartbeat, should also be careful when using UPNEEQ.
  • Patients who use a certain class of antidepressant medication (monoamine oxidase inhibitors) should also be careful when using UPNEEQ, as it may affect the way your body absorbs the medication.

These are not all of the possible side effects of UPNEEQ. Tell your doctor if you have any side effect that bothers you or does not go away. Call your doctor for medical advice about side effects.
To report side effects or product complaints, contact RVL Pharmaceuticals at 1-877-482-3788. You may also report side effects to the FDA by calling 1-800-FDA-1088 or visit www.fda.gov/medwatch.
This is a summary of the most important safety information for UPNEEQ. For more in-depth safety information, please review the full Prescribing Information for UPNEEQ.