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Live with eyes wide open

The first and only FDA-approved eyedrop for adults with low-lying eyelids

Meet Upneeq

Upneeq lifts tired-looking eyelids fast

Meet Upneeq® (oxymetazoline hydrochloride ophthalmic solution), 0.1%, the first and only FDA-approved prescription eye drop for adults with low-lying eyelids (also known as acquired blepharoptosis or ptosis). It provides a non-surgical eyelid lift, quickly lifting eyelids for more awake-looking eyes.

Just one drop per affected eye, once daily, is clinically proven to give visible results — lifted and more open eyelids in as fast as 5 minutes that can last up to 8 hours.

Say bye-bye to tired-looking eyelids, and hello to a refreshed, more awake-looking you. See what it feels like to live with eyes wide open. If you have low-lying eyelids, find out if Upneeq is right for you.

BEFORE
AFTER
After
Before

Individual results may vary. Average upper eyelid lift with Upneeq in clinical studies was 1 mm.

DO YOU HAVE LOW-LYING EYELIDS?

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Experience Upneeq

Visible results

When it comes to eyelids, a little lift goes a long way. Upneeq provides a non-surgical eyelid lift that is clinically proven to lift and open upper eyelids.

Fast-acting, long-lasting

Just one drop in each eye can temporarily lift upper eyelids in as little as 5 minutes, and last up to 8 hours.

Easy to incorporate

Our single-use vials are FDA-approved for once daily use, making it easy to lift low-lying eyelids in your everyday routine for a brighter, more awake-looking appearance.

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IN CLINICAL TRIALS OF UPNEEQ:

84%

of patients have had some form of improvement in eyelid lift.

88%

of patients have had some form of improvement in their upper field of vision.

AS SEEN IN

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Learn more about acquired ptosis

If your eyelids appear droopy or tired, you may have acquired ptosis, and be a candidate for Upneeq. To determine if Upneeq is a good fit for you, you’ll need to schedule a consultation with a healthcare professional or telemedicine provider.

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Real patients, real eye-opening results

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Get started with Upneeq

Upneeq is the only FDA-approved, prescription eye drop that lifts low-lying eyelids (acquired ptosis). Find out if Upneeq’s eye-opening benefits are right for you.

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UPNEEQ INSIGHTS

correcting-ptosis-card-cover

Correcting Ptosis

If you or someone you know has been diagnosed with acquired ptosis, also known as drooping eyelids, you might be exploring ways to treat this condition. Ptosis not only affects your appearance but can also impair your vision and quality of life.

Read more

why-do-i-look-tired-card-cover

Why Do I Look Tired?

If you frequently find yourself asking, "Why do I look tired?" despite getting enough rest, it may be worthwhile to explore whether acquired ptosis could be the reason.

Read more

diagnosing-ptosis-card-cover

Diagnosing Ptosis: What to Expect When You Visit Your Doctor

Understanding the steps involved in diagnosing ptosis can demystify the process and help you prepare for your doctor's visit. If you suspect you have acquired ptosis, don’t hesitate to consult with your doctor to learn more and discuss the best treatment options tailored to your condition.

Read more

IMPORTANT SAFETY INFORMATION


What is UPNEEQ?

UPNEEQ® (oxymetazoline hydrochloride ophthalmic solution), 0.1% is a prescription eyedrop used to treat acquired blepharoptosis (low-lying lids) in adults.


What warnings and precautions are associated with UPNEEQ?

  • Low-lying lids may be related to conditions such as stroke and/or brain aneurysm, Horner syndrome, myasthenia gravis, loss of the ability to move eye muscles, eye infection and eye tumors. Tell your doctor if you have any of these conditions.
  • UPNEEQ is a type of medication that may affect your blood pressure. If you have heart disease, uncontrolled high or low blood pressure, or feel faint at rest or when quickly standing up, you should call your doctor if your symptoms get worse.
  • Patients with reduced blood flow to the brain or heart, or patients who experience eye or mouth dryness due to an immune system disorder (Sjögren’s syndrome), should use care when taking UPNEEQ. Call your doctor immediately if you feel your symptoms may be getting worse.
  • UPNEEQ may increase the risk of eye pressure due to fluid buildup (angle-closure glaucoma) in patients with untreated narrow-angle glaucoma. Call your doctor immediately if you feel increased pressure in your eye after using UPNEEQ.
  • Do not let the tip of the UPNEEQ vial touch your eye or any other surface. This can help prevent eye injury or contamination. Each UPNEEQ vial is for one-time use and should be discarded after being used.

What are the most common side effects of UPNEEQ?

The most common adverse reactions with UPNEEQ (occurring in 1-5% of patients) were eye inflammation, eye redness, dry eye, blurred vision, eye pain at time of use, eye irritation, and headache.


What should my doctor know about before prescribing me UPNEEQ?


  • Your doctor should review your full medical history before prescribing UPNEEQ.
  • UPNEEQ belongs to a class of medication (alpha-adrenergic agonists) that may affect your blood pressure. Use UPNEEQ carefully if you currently take an alpha-adrenergic agonist medication to treat heart disease or an enlarged prostate. Patients taking beta-blockers, or other medications to treat hypertension or an abnormal heartbeat, should also be careful when using UPNEEQ.
  • Patients who use a certain class of antidepressant medication (monoamine oxidase inhibitors) should also be careful when using UPNEEQ, as it may affect the way your body absorbs the medication.

These are not all of the possible side effects of UPNEEQ. Tell your doctor if you have any side effect that bothers you or does not go away. Call your doctor for medical advice about side effects.
To report side effects or product complaints, contact RVL Pharmaceuticals at 1-877-482-3788. You may also report side effects to the FDA by calling 1-800-FDA-1088 or visit www.fda.gov/medwatch.
This is a summary of the most important safety information for UPNEEQ. For more in-depth safety information, please review the full Prescribing Information for UPNEEQ.

IMPORTANT SAFETY INFORMATION


What is UPNEEQ?

UPNEEQ® (oxymetazoline hydrochloride ophthalmic solution), 0.1% is a prescription eyedrop used to treat acquired blepharoptosis (low-lying lids) in adults.


What warnings and precautions are associated with UPNEEQ?

  • Low-lying lids may be related to conditions such as stroke and/or brain aneurysm, Horner syndrome, myasthenia gravis, loss of the ability to move eye muscles, eye infection and eye tumors. Tell your doctor if you have any of these conditions.
  • UPNEEQ is a type of medication that may affect your blood pressure. If you have heart disease, uncontrolled high or low blood pressure, or feel faint at rest or when quickly standing up, you should call your doctor if your symptoms get worse.
  • Patients with reduced blood flow to the brain or heart, or patients who experience eye or mouth dryness due to an immune system disorder (Sjögren’s syndrome), should use care when taking UPNEEQ. Call your doctor immediately if you feel your symptoms may be getting worse.
  • UPNEEQ may increase the risk of eye pressure due to fluid buildup (angle-closure glaucoma) in patients with untreated narrow-angle glaucoma. Call your doctor immediately if you feel increased pressure in your eye after using UPNEEQ.
  • Do not let the tip of the UPNEEQ vial touch your eye or any other surface. This can help prevent eye injury or contamination. Each UPNEEQ vial is for one-time use and should be discarded after being used.

What are the most common side effects of UPNEEQ?

The most common adverse reactions with UPNEEQ (occurring in 1-5% of patients) were eye inflammation, eye redness, dry eye, blurred vision, eye pain at time of use, eye irritation, and headache.


What should my doctor know about before prescribing me UPNEEQ?


  • Your doctor should review your full medical history before prescribing UPNEEQ.
  • UPNEEQ belongs to a class of medication (alpha-adrenergic agonists) that may affect your blood pressure. Use UPNEEQ carefully if you currently take an alpha-adrenergic agonist medication to treat heart disease or an enlarged prostate. Patients taking beta-blockers, or other medications to treat hypertension or an abnormal heartbeat, should also be careful when using UPNEEQ.
  • Patients who use a certain class of antidepressant medication (monoamine oxidase inhibitors) should also be careful when using UPNEEQ, as it may affect the way your body absorbs the medication.

These are not all of the possible side effects of UPNEEQ. Tell your doctor if you have any side effect that bothers you or does not go away. Call your doctor for medical advice about side effects.
To report side effects or product complaints, contact RVL Pharmaceuticals at 1-877-482-3788. You may also report side effects to the FDA by calling 1-800-FDA-1088 or visit www.fda.gov/medwatch.
This is a summary of the most important safety information for UPNEEQ. For more in-depth safety information, please review the full Prescribing Information for UPNEEQ.

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Distributed by: RVL Pharmaceuticals, Inc. Bridgewater, NJ 08807.©2024 RVL Pharmaceuticals, Inc. All rights reserved. PM-US-UPN-1594-09/24

Upneeq® is a registered trademark of RVL Pharmaceuticals, Inc.